| Congresso Brasileiro de Microbiologia 2023 | Resumo: 971-2 | ||||
Resumo:Klebsiella pneumoniae is an important gram-negative opportunistic pathogen that causes a variety of infectious diseases, including urinary tract infections, bacteremia, pneumonia, and liver abscesses. The increase in infections caused by K. pneumoniae in recent years is due to its great capacity for adaptation and resistance in the hospital environment. The aim of this study was to verify the prevalence of K. pneumoniae among gram-negative bacilli (GNB) and the sensitivity profile of these microorganisms isolated from patients admitted to Hospital Regional Norte (HRN) in Sobral, Ceará. From April to November 2021, microbiological data were collected by the Hospital Infection Control Commission (HICC) of the HRN from hospitalized patients with nosocomial infections, with a total of 251 samples obtained. Of these, 29.8% were collected from urine, 28.6% from blood, 23.5% from tracheal aspirate, 2.3% from tissue fragments, 1.5% from surgical wound, 1.1% from pleural fluid, and 1.1% from liquor. The prevalence of K. pneumoniae found was 29.8%, followed by Acinetobacter baumannii (17.5%) and Pseudomonas aeruginosa (15.1%). The antimicrobial susceptibility test (AST) showed that 73.9% of the K. pneumoniae isolates were sensitive to Amikacin, 67.7% to Colistin, 52% to Imipenem, 39.7% to Gentamicin, 37% to Meropenem, 34 .2% to Ertapenem, 29.8% to Trimethoprim, 24% to Levoflaxacin, 20% to Cefepime, 15% to Ceftazidime. On the other hand, 56% produced extended-spectrum β-lactamases (ESBL). Therefore, the results of this study demonstrated a higher prevalence of infections by K. pneumoniae than by other GNB among patients with healthcare-associated infection in the HRN, having been isolated mainly from urinary tract infections and blood of female individuals. In addition, the AST showed that the antimicrobials Amikacin and Colistin were the most indicated for the treatment of infections caused by this bacterium. A character of multi-drug resistance was also observed among the specimens, which highlights the urgent need to control the use of antimicrobials in the referred hospital. Palavras-chave: Antimicrobial resistance, healthcare-associated infection, Klebsiella pneumoniae Agência de fomento:Universidade Federal do Ceará, Campus Sobral – CE | |||||